We have found that existing preclinical evidence strongly supports CBD as a treatment for generalised anxiety disorder, panic disorder, social anxiety disorder, obsessive-compulsive disorder and post-traumatic stress disorder when administered acutely; however, few studies have investigated chronic CBD dosing. HV = healthy volunteers; DBP = double-blind placebo; SAD = social anxiety disorder; HC = healthy controls; THC = Δ9-tetrahydrocannabinol; STAI = Spielberger state-trait anxiety inventory; VAMS = visual analogue mood scale; BP = blood pressure; SPST = speech simulation test; SCR = skin conductance response; SPECT = single photon emission computed tomography; SSPS-N = negative self-assessment subscale; HR = heart rate; VAS = visual analogue scale, CBD = cannabidiol. A decrease in anxiety symptoms was found in 57 of the study participants and it was concluded that CBD may be beneficial for anxiety-related disorders. For generalised anxiety disorder (GAD), the National Institute on Drug Abuse (NIDA) states that CBD has been shown to reduce stress in animals such as rats.
While some research seems to indicate that CBD may be beneficial in the treatment of anxiety-related disorders, more studies are needed. Overall, current evidence suggests that CBD has considerable potential as a treatment for multiple anxiety disorders, with the need for further study of chronic and therapeutic effects in relevant clinical populations. Overall, the existing preclinical evidence strongly supports the potential of CBD as a treatment for anxiety disorders. CBD = cannabidiol; HV = healthy controls; DBP = double-blind placebo; SAD = social anxiety disorder; HC = healthy controls; SPECT = single-photo emission computed tomography; rCBF = regional cerebral blood flow; fMRI = functional magnetic resonance imaging; HPC = hippocampus; HYP = hypothalamus; PHG = parahippocampal gyrus; STG = superior temporal gyrus; MTG = medial temporal gyrus; ACC = anterior cingulate cortex; PCC = posterior cingulate cortex.Overall, this review highlights the potential value and need for further studies on CBD in the treatment of anxiety disorders.
A large retrospective case series in a psychiatric clinic involving the clinical application of CBD for anxiety and sleep disorders as an adjunct to treatment as usual. A retrospective review of the clinical records of adult psychiatric patients treated with CBD for anxiety or sleep as an adjunct to routine treatment in a large psychiatric outpatient clinic was conducted.