Under acidic conditions, CBD can be converted into delta9- tetrahydrocannabinol (THC) and other cannabinoids. Currently, two studies suggest that CBD could be converted into THC. The first used simulated gastric fluid, devoid of pepsin, to reproduce the conditions that CBD would experience when ingested orally. The researchers found that delta-9-THC was present at a conversion rate of 2.Although Merrick cites Watanabe's work to build the case for CBD to THC conversion in the stomach, Merrick's experiment is surprisingly inconsistent with Watanabe's data.
In Watanabe's simulated gastric fluid study, 15.less than 3 percent of CBD was actually converted to THC in this experiment, which lasted 20 hours - far longer than CBD stays in the stomach. However, Merrick's paper proposed that 85% of CBD is broken down in a single hour. In other words, the reaction that occurred in Merrick's study was more than 200 times faster than the reaction in Watanabe's study. Pharmacokinetic research (Huestis 2007) on how THC, CBD and other cannabinoids interact and affect the body claims that CBD can actually decrease the side effects of THC when taken simultaneously.
They found that CBD was converted to Δ8-THC and Δ9-THC in simulated gastric fluid, but that the conversion did not occur when CBD was tested in a non-gastric physiological solution. In any case, knowing that CBD converts to THC quite easily in acidic conditions, many people have had the keen concept of buying legal CBD, and then transforming it into mind-altering THC in a DIY lab, Walter White-style. You could be forgiven for thinking that the two have similar effects, but they do not, although CBD and THC work together and make the effects of THC less potent. Moreover, available research suggests that even if CBD were converted to THC, the amount of THC would be so minimal that it would have no physiological or behavioural consequences.
Fortunately, the World Health Organisation, a global body dedicated to the welfare of mankind, has compiled the relevant information as part of its comprehensive review of CBD. Although the results of both studies appear conclusive, CBD exposed to simulated gastric fluid does not replicate the entire process within the human body. Therefore, broad-spectrum CBD products are less likely to contain THC than full-spectrum CBD products. Remember that CBD products derived from marijuana, along with full-spectrum CBD products derived from hemp, are more likely to contain THC.
The conversion of CBD to THC, previously documented by Gaoni and Mechoulam (1968), did not occur under simulated gastric conditions, but took place in a very unnatural environment with CBD dissolved in sulphuric acid and methanol. We won't go into too much detail here in this essay, but fundamentally, the key distinction between CBD and THC is the fact that CBD does not get you high. However, if CBD is metabolised into THC, as a recent report published in Cannabis and Cannabinoid Research states, the overall safety profile of CBD could be at risk.